Camptothecin biosynthesis
WebBiosynthesis-inspired mining and identification of untapped alkaloids in Camptotheca acuminate for enzyme discovery using ultra-high performance liquid chromatography … WebInvestigations have shown that the glycerophospholipid PGP is a PTPMT1 target and regulates cardiac phospholipid biosynthesis and mitochondrial ... Qiu L, Li J, Ying K, Guo C, Zhang J. Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. FEBS Lett. 2009; …
Camptothecin biosynthesis
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WebJun 22, 2016 · To unveil the CPT biosynthesis pathway, many efforts have been done for pathway gene identification and the application of large-scale RNA-sequencing technique accelerated screening of candidate genes which could be involved in CPT biosynthesis. WebOct 30, 2011 · Camptothecin (CPT) was first extracted from the stems of Camptotheca acuminata in 1966 and subsequently from Nothapodytes foetida, Ophiorrhiza pumila, and Ophiorrhiza japonica [ 1 ]. CPT exhibits clinical anti-tumor activity by inhibiting DNA topoisomerase I, an enzyme involved in DNA recombination, repair, replication, and …
WebMay 22, 2024 · Camptothecin (CAM) is a well-known, complex, plant-derived antitumor monoterpenoid indole alkaloid (MIA). Featuring a unique pentacyclic pyrroloquinoline scaffold, CAM is biosynthetically distinct from the other known MIAs, such as antitumor vincristine and vinblastine. WebApr 10, 2024 · The compound camptothecin showed hydrogen bond interaction with A:TYR73, A:ASN69, and A:SER60, while hydrophobic interaction with A:PHE67 (Fig. 1 B, Table 1 A). ... Management of melanin biosynthesis dehydratase inhibitor (MBI-D)-resistance in pyricularia oryzae using a non-MBI-D fungicidal application program for …
WebJan 15, 2024 · The camptothecin biosynthesis pathway and the mechanisms regulating its production remain unknown, even though it is one of the most promising plant-derived … WebJan 16, 2004 · Camptothecin derivatives are clinically used antitumor alkaloids that belong to monoterpenoid indole alkaloids. In this study, we investigated the biosynthetic pathway of camptothecin from [1- 13 C]glucose (Glc) by in silico and in vivo studies.
WebMay 16, 2014 · Current Biology May 10, 2024. Autophagy is a conserved, multi-step process of capturing proteolytic cargo in autophagosomes for lysosome degradation. The capacity to remove toxic proteins that ...
WebJun 16, 2024 · The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza … bing search automator edgeWebCamptothecin. Camptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the … bing search bar in firefox not workingWebJan 6, 2024 · The actual and predicted yield of camptothecin by A. terreus was noticeably fluctuated from 10.5 to 170.5 μg/L, confirming the significance of the tested variables on camptothecin biosynthesis, and the efficiency of the Plackett–Burman design, the values of the coefficient of determination (R2 = 0.98) indicating the goodness-of-fit measure ... bing search baronWebDec 2, 2024 · Camptothecin (CPT), a natural alkaloid isolated from Camptotheca acuminata Decne, is found to show potential insecticidal activities with unique action mechanisms by targeting at DNA … bing search bar disappearedWebNov 14, 2016 · The main precursor for the biosynthesis of camptothecin and many other important alkaloids including some important anti-cancer molecules is strictosidine, which is synthesized by the action of strictosidine synthase from tryptamine and secologanin (STR1) (Figure (Figure4) 4) (Panjikar et al., 2012). daams graphicsWebOct 17, 2024 · Topoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of … daan creyghton showsWebThe hairy roots (HR) of Ophiorrhiza pumila produce camptothecin (CPT), a monoterpenoid indole alkaloid used as a precursor in the synthesis of chemotherapeutic drugs. O. pumila HR culture is considered as a promising alternative source of CPT, bing search bar character