WebDec 1, 2024 · One of the most intriguing unresolved issues regarding CBP and p300 biology is the overlap of their functions. Structurally, they display 57% identity at the whole protein level and 88% similarity in their KAT domains ( Figure 1a), and as indicated before, the elimination of either one of these two proteins results in early embryonic death. WebJun 1, 2024 · The CREB-binding protein (CREBBP, in short CBP) is a transcriptional co-activator with lysine acetyltransferase activity. CBP has been reported to be involved in various cellular processes including cell metabolism, embryonic development and cell differentiation 5-8.
Q92793 - UniProt
WebThe CREBBP gene provides instructions for making CREB binding protein, which regulates the activity of many genes in tissues throughout the body. This protein plays an essential role in controlling cell growth and division and prompting cells to mature and assume specialized functions (differentiate). WebCREBBP (HGNC:2348) HGNC Entrez Ensembl OMIM UCSC Uniprot GeneReviews LOVD LSDB ClinVar HGNC Name CREB binding protein Gene type protein-coding gene Locus type gene with protein product Previous symbols RSTS Alias symbols RTS, CBP, KAT3A GenCC Classifications Definitive 4 Strong 1 Moderate 1 (Read more about GenCC … ismat mehdi advocates
OMIM Entry - * 600140 - CREB-BINDING PROTEIN; CREBBP
WebCBP is a large protein with a molecular mass of about 250 kD which contains a bromodomain, i.e., a conserved structural unit important for protein-protein interactions. In Drosophila and yeast, this domain is found in coactivator proteins involved in signal-dependent, but not basal, transcription (Nordheim, 1994). WebItem KAT3A / CBP (CREBBP) Human qPCR Primer Pair (NM_004380) Company OriGene Technologies; Price Pricing Info Supplier Page View Company Product Page; Catalog Number HP229628; Quantity 200 reactions; Type qPCR Primer Pairs; Target CREBBP; Species Human; NCBI Full Gene Name CREB binding protein; NCBI Gene Aliases CBP, … WebMar 9, 2011 · CREBBP is expressed in leukaemic cells and normal B-cell progenitors ( Supplementary Fig. 4 ), and the mutant CREBBP alleles are expressed in ALL cell lines harbouring mutations ( Supplementary... is matlock still alive