Siglec family
WebUsing the Stanford G3 radiation hybrid panel we were able to localize the genomic sequence of siglec-10 within the cluster of genes on chromosome 19q13.3-4 that encode other … WebIt is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin …
Siglec family
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Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand … See more The first described candidate Siglec was Sialoadhesin (Siglec-1/CD169) a lectin-like adhesion protein on macrophages. Parallel studies by Ajit Varki and colleagues on the previously cloned CD22 (a B cell surface protein involved in See more The primary function of Siglecs is to bind glycans containing sialic acids. These receptor-glycan interactions can be used in cell adhesion, cell … See more Many pathologies have been linked to the spontaneous interactions between sialic acid and the immunosuppressive sialic acid-binding … See more Siglecs are Type I transmembrane proteins where the NH3 -terminus is in the extracellular space and the COO -terminus is See more This table briefly summarises the cellular distribution of each human/primate Siglec; the linkage specificity each has for sialic acid binding; the number of C2-Ig domains it contains; and … See more • Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group • I-type Lectins (Siglecs) Research conducted at Imperial College London providing another overview of I-type Lectins See more
WebJun 15, 2024 · Siglec 受体Siglec family. ... 所有 Siglecs 都是单通道 1 型整合膜蛋白，含有一个（或两个，在 Siglec-12 的情况下）独特且同源的 N 端 V 组 Ig 结构域的细胞外结构域，然后是可变数量的 C2 组 Ig 结构域，范围从唾液酸粘附素中的 16 到 CD33 中的 1。 WebA new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 Gena Whitney1, Shulin Wang1, Han Chang2, Ke-Yi …
Web“An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+mononuclear cells and PDGF-BB secretion”出自《骨研究(英文版)》期刊2024年第4期文献，主题关键词涉及有等。钛学术提供该文献下载服务。 WebCD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro).
WebJan 25, 2024 · The Siglec family in humans has 14 members that are believed to bind a diverse range of glycoprotein and glycolipid substrates on the surface of cancer cells . …
WebApr 10, 2024 · The Siglec-Fc protein, a fusion protein combining Siglec with the Fc part of a human antibody, is a promising sialic acid-Siglec axis-targeted agent for cancer treatment … detached bungalows for sale wolverhamptonWebCD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some … chum basketWebApr 24, 2024 · Dasatinib is a highly potent, ATP competitive inhibitor of both Src and Bcr-Abl, with K s of 16 pM and 30 pM, respectively. Moreover, Dasatinib potently inhibits other Src … detached bungalows in blackpoolWebI-type lectins are defined as glycan-binding proteins (excluding antibodies and T-cell receptors) in which the binding domain is homologous to the large and varied immunoglobulin superfamily (IgSF) of proteins. Among I … chumba support hotlineWebNov 13, 2024 · Siglec-8, a CD33-related family member, is often found on human eosinophils, mast cells, and weakly on basophils . Although it can exist as two spliced … chumba refer a friendWebJan 3, 2024 · Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved … chumba translationCD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. detached bungalows in bingley